Evaluation of buffy coat 16S rRNA PCR, buffy coat culture and whole blood PCR for detection of bacteraemia

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Evaluation of buffy coat 16S rRNA PCR, buffy coat culture and whole blood PCR for detection of bacteraemia.

The use of Gram type-specific PCR on buffy coat from clinical specimens for the detection of bacteraemia was evaluated for the first time using whole blood culture as the gold standard. In addition, the established buffy coat culture and whole blood PCR were also compared. Gram-positive bacteria belonging to six species and Gram-negative bacteria from 10 species were isolated and identified by ...

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Optimized factor V gene mutation detection using buffy-coat direct PCR.

Activated protein C-resistance (APC-resistance) (6) is the most common inherited genetic disorder responsible for venous thrombosis (13). Over 90% of APC-resistances are caused by a single-base mutation, G/A 1691 in the factor V gene, also known as factor V Leiden. This mutation, changing Arg 506 to Gln, impedes the cleavage of factor Va by APC (3,7,14). APC-resistance is routinely determined b...

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Evaluation of buffy coat microscopy for the early diagnosis of bacteraemia-meningococcal septicaemia.

Three hundred and sixty samples of blood from 230 hospital patients were examined and compared with the results of simultaneous blood culture to determine the value of buffy-coat microscopy in detecting bacteraemia. One observer found 86 positive smears, 12 of which were from patients with positive blood cultures and 74 from patients with negative blood cultures. The buffy-coat smear was negati...

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Buffy Coat in Diagnosis of Pulmonary Tuberculosis

Background: Besides charging the patients with outstanding costs, tuberculosis (TB) causes high mortality and morbidity in a country. We studied the sensitivity, specificity, positive and negative predictive values as well as the efficiency of buffy coat smear test in patients who were pulmonary TB suspects. This research was conducted at Massih Daneshvari Hospital, National Research Institute ...

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Comparison of multiplex and ordinary PCR for diagnosis of paratuberculosis and tuberculosis in blood samples (buffy coat) of cattle and buffaloes

Background: Paratuberculosis and tuberculosis (TB) caused by Mycobacterium avium paratuberculosis (MAP) and Mycobacterium tuberculosis complex (MTC), respectively are economically important, chronic debilitating diseases affecting the dairy herds and are also potential zoonotic threats. Aims: Differential diagnosis of paratuberculosis and TB i...

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ژورنال

عنوان ژورنال: Memórias do Instituto Oswaldo Cruz

سال: 2010

ISSN: 0074-0276

DOI: 10.1590/s0074-02762010000200001